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ALIMENTARY TRACT AND METABOLISM › ANTIDIARRHEALS, INTESTINAL ANTIINFLAMMATORY/ANTIINFECTIVE AGENTS › INTESTINAL ANTIINFLAMMATORY AGENTS › Corticosteroids acting locally
tixocortol
A07EA05
Forms & Strengths
- Tablets: 2.5mg
- Suppositories: 2.5mg, 5mg
- Enema: 5mg/5mL
Adult Dosing
- Usual dose: 2.5mg to 5mg per day
- Maximum dose: 10mg per day
- Duration of treatment: up to 7 days
Pediatric Dosing
- Children under 3 years: not recommended
- Children 3-12 years: 1.25mg to 2.5mg per day
- Children over 12 years: adult dose
Indications
- Treatment of ulcerative colitis
- Treatment of proctitis
- Treatment of rectal inflammation
Mechanism of Action
- Corticosteroid with local anti-inflammatory effects
- Inhibits the release of inflammatory mediators
- Reduces edema, redness, and pain in the rectal mucosa
Contraindications
- Hypersensitivity to tixocortol or corticosteroids
- Active tuberculosis
- Fungal or viral infections
Adverse Reactions
- Rectal irritation or burning
- Increased risk of GI perforation
- Cushing's syndrome with long-term use
- Adrenal suppression
Drug Interactions
- CYP3A4 inhibitors: increased tixocortol levels
- CYP3A4 inducers: decreased tixocortol levels
- Concurrent use of NSAIDs: increased risk of GI adverse effects
Curated Content: Needs Vetting Before Put to Clinical Use