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ALIMENTARY TRACT AND METABOLISM › ANTIDIARRHEALS, INTESTINAL ANTIINFLAMMATORY/ANTIINFECTIVE AGENTS › ANTIDIARRHEAL MICROORGANISMS › Antidiarrheal microorganisms
lactic acid producing organisms, combinations
A07FA51
Forms & Strengths
- Capsule
- Tablet
- Powder for oral suspension
- 1 billion CFU
- 2 billion CFU
- 5 billion CFU
Adult Dosing
- 1-2 capsules or tablets orally per day
- 1-2 billion CFU per day
- Take with food to reduce gastrointestinal side effects
Pediatric Dosing
- 0.5-1 billion CFU per day for children under 12
- 1-2 billion CFU per day for children over 12
- Administer with food
Indications
- Treatment and prevention of antibiotic-associated diarrhea
- Irritable bowel syndrome
- Inflammatory bowel disease
- Lactose intolerance
- Vaginal infections
Mechanism of Action
- Recolonization of the gut with beneficial microorganisms
- Production of lactic acid to create an acidic environment
- Inhibition of pathogenic bacteria growth
- Enhancement of the intestinal barrier function
Contraindications
- Severe immunodeficiency
- Short bowel syndrome
- Graft-versus-host disease
- Sepsis or bacteremia
Adverse Reactions
- Gastrointestinal upset
- Abdominal bloating
- Flatulence
- Diarrhea
- Allergic reactions
Drug Interactions
- Reduces absorption of certain medications (e.g. ciprofloxacin, tetracycline)
- Interacts with immunosuppressants
- Concomitant use with antacids may reduce efficacy
Curated Content: Needs Vetting Before Put to Clinical Use