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diastase

A09AA01

Forms & Strengths

Oral liquid: Diastase 50 mg/pepsin 10 mg per 5 mL
Oral syrup: Fungal diastase (1:1200) 20 mg/mL
Combination enzyme tablets: Diastase combined with papain, pepsin, and pancreatin

Adult Dosing

Fungal diastase: 1 to 2 teaspoonfuls (5 to 10 mL) or 1 to 2 tablets orally immediately after meals
Dose frequency: 2 to 3 times daily as needed for digestive support

Pediatric Dosing

Children > 12 years: 1 teaspoonful (5 mL) or 1 tablet orally after meals
Children < 12 years: Safety and efficacy not well established; use only under direct medical supervision

Indications

Digestive aid for dyspepsia and carbohydrate maldigestion
Adjuvant therapy in pancreatic exocrine insufficiency and chronic gastritis
Relief of flatulence, abdominal distension, and postprandial fullness

Mechanism of Action

Acts as a digestive enzyme supplement containing amylolytic enzymes derived from fungi or plants
Hydrolyzes complex carbohydrates, starches, and polysaccharides into simpler dextrins and maltose to facilitate gastrointestinal absorption

Contraindications

Hypersensitivity to diastase, fungal proteins, or any component of the formulation
Acute pancreatitis or acute exacerbations of chronic pancreatitis
Known porcine or fungal allergy depending on the enzyme source

Adverse Reactions

Gastrointestinal: Nausea, abdominal cramps, diarrhea, or perianal irritation with high doses
Hypersensitivity: Skin rash, urticaria, pruritus, or anaphylaxis in rare cases
Stomatitis or oral mucosal ulceration with prolonged direct contact of powder or tablets

Drug Interactions

Antacids and H2-blockers/PPIs: May inactivate or reduce the enzymatic efficacy of diastase in an altered gastric pH environment
Acarbose and miglitol: Alpha-glucosidase inhibitors may theoretically antagonize or be affected by carbohydrate-digesting enzymes
Pancreatic enzyme supplements: Concurrent use may lead to additive gastrointestinal side effects

Curated Content: Needs Vetting Before Put to Clinical Use