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hydrochloric acid

A09AB03

Forms & Strengths

Dilute Hydrochloric Acid: 10% solution, oral
Gastric acidifier preparations in combination with pepsin

Adult Dosing

Dilute Hydrochloric Acid (10%): 5 to 10 mL diluted in at least 100 mL of water, taken with meals using a straw to protect teeth
Administer 3 times daily during or immediately following meals for conditions of achlorhydria or hypochlorhydria

Pediatric Dosing

Safety and efficacy in pediatric patients have not been firmly established
Use is generally off-label and requires specialist supervision if indicated for severe hypochlorhydria

Indications

Treatment of severe hypochlorhydria or achlorhydria
Gastric acid replacement therapy in specific malabsorption states

Mechanism of Action

Replenishes exogenous hydrochloric acid in the stomach
Lowers gastric pH to activate pepsinogen into pepsin, aiding in protein digestion and mineral absorption

Contraindications

Hyperchlorhydria
Active peptic ulcer disease
Severe renal impairment
History of corrosive ingestion or severe esophageal strictures

Adverse Reactions

Dental enamel erosion (if not ingested through a straw or rinsed immediately)
Gastric irritation
Nausea
Abdominal discomfort
Acidosis with chronic excessive use

Drug Interactions

Alkalinizing agents (antacids, proton pump inhibitors, H2 blockers) decrease the therapeutic efficacy of hydrochloric acid
May alter the absorption of concurrent medications dependent on acidic gastric pH for optimal bioavailability (e.g., ketoconazole, iron salts)

Curated Content: Needs Vetting Before Put to Clinical Use