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insulin (pork)

A10AB03

Forms & Strengths

Injection: 100 units/mL (U-100) in 10 mL vials

Adult Dosing

Subcutaneous: Individualized based on blood glucose monitoring, metabolic needs, and meal patterns
Type 1 Diabetes: Typically 0.2 to 0.6 units/kg/day divided into multiple daily doses (prandial and basal)
Intravenous: Regular pork insulin used in acute clinical settings (e.g., DKA) under strict protocols

Pediatric Dosing

Subcutaneous: Individualized based on weight, age, and pubertal status
Initial total daily dose: Typically 0.2 to 0.5 units/kg/day, adjusted based on glycemic control

Indications

Glycemic control in patients with type 1 diabetes mellitus
Glycemic control in patients with type 2 diabetes mellitus requiring insulin therapy
Management of diabetic ketoacidosis or hyperosmolar hyperglycemic state (via IV infusion)

Mechanism of Action

Binds to insulin receptors on muscle and fat cells, facilitating cellular uptake of glucose
Inhibits hepatic gluconeogenesis and glycogenolysis
Promotes anabolic processes including lipogenesis and protein synthesis while inhibiting lipolysis

Contraindications

Hypoglycemia
Hypersensitivity to pork insulin or any excipients in the formulation

Adverse Reactions

Hypoglycemia (common, potentially severe)
Weight gain
Hypokalemia
Injection site reactions (lipodystrophy, lipoatrophy, pruritus, erythema)
Allergic reactions, including anaphylaxis and generalized skin rashes

Drug Interactions

Glucose-lowering agents (sulfonylureas, GLP-1 receptor agonists, SGLT2 inhibitors): May increase hypoglycemia risk
Corticosteroids, thiazide diuretics, sympathomimetics, atypical antipsychotics: May decrease blood glucose-lowering effect
Beta-blockers: May mask symptoms of hypoglycemia (e.g., tachycardia, tremors) and prolong hypoglycemic episodes
Alcohol: Can potentiate hypoglycemia or cause delayed hyperglycemia depending on consumption patterns

Curated Content: Needs Vetting Before Put to Clinical Use