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ALIMENTARY TRACT AND METABOLISM › DRUGS USED IN DIABETES › INSULINS AND ANALOGUES › Insulins and analogues for injection, intermediate-acting
insulin (beef)
A10AC02
Forms & Strengths
- Injectable suspension 100 units/mL (U-100)
Adult Dosing
- Subcutaneous: Individualized based on blood glucose monitoring, metabolic needs, and clinical response
- Typically administered 15-30 minutes before meals
Pediatric Dosing
- Subcutaneous: Individualized based on blood glucose monitoring, weight, and pubertal status
- Total daily dose generally ranges from 0.5 to 1.0 units/kg/day in divided doses
Indications
- Treatment of type 1 diabetes mellitus
- Treatment of type 2 diabetes mellitus inadequately controlled by diet, oral agents, and non-insulin injectables
Mechanism of Action
- Binds to insulin receptors on muscle and fat cells
- Stimulates cellular uptake of glucose
- Inhibits hepatic gluconeogenesis and glycogenolysis
- Reduces blood glucose levels and promotes anabolic processes
Contraindications
- Hypoglycemia
- Hypersensitivity to beef insulin or any excipient in the formulation
Adverse Reactions
- Hypoglycemia
- Weight gain
- Lipodystrophy at injection sites
- Injection site reactions (pain, erythema, pruritus)
- Hypersensitivity reactions including anaphylaxis
- Hypokalemia
Drug Interactions
- Oral antidiabetic agents, ACE inhibitors, disopyramide, fibrates, fluoxetine, MAO inhibitors, pentoxifylline, propoxyphene, salicylates, and sulfonamides may increase hypoglycemic effects
- Atypical antipsychotics, corticosteroids, danazol, diuretics, estrogens, glucagon, isoniazid, niacin, oral contraceptives, phenothiazines, sympathomimetics, and thyroid hormones may decrease blood glucose-lowering effects
- Beta-blockers, clonidine, guanethidine, and reserpine may mask or blunt the symptoms of hypoglycemia
Curated Content: Needs Vetting Before Put to Clinical Use