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ALIMENTARY TRACT AND METABOLISM › DRUGS USED IN DIABETES › INSULINS AND ANALOGUES › Insulins and analogues for injection, intermediate-acting
insulin (pork)
A10AC03
Forms & Strengths
- Injection: 100 units/mL (U-100) in 10 mL vials
Adult Dosing
- Type 1 or Type 2 Diabetes Mellitus: Individualized based on blood glucose monitoring, typically 0.2 to 0.6 units/kg/day divided in multiple daily injections (basal-bolus regimens)
Pediatric Dosing
- Type 1 Diabetes Mellitus: Individualized, typically 0.2 to 1.0 units/kg/day divided in multiple daily injections based on age, weight, and pubertal status
Indications
- Treatment of diabetes mellitus requiring insulin for the control of hyperglycemia
Mechanism of Action
- Binds to insulin receptors on muscle and fat cells, facilitating cellular glucose uptake and inhibiting hepatic glucose output, lipolysis, and proteolysis
Contraindications
- Episodes of acute hypoglycemia
- Hypersensitivity to pork insulin or any excipient in the formulation
Adverse Reactions
- Hypoglycemia (common, dose-limiting)
- Weight gain
- Lipodystrophy or lipoatrophy at injection sites
- Allergic reactions (local or systemic hypersensitivity)
- Hypokalemia
Drug Interactions
- Oral antidiabetic agents, ACE inhibitors, disopyramide, fibrates, fluoxetine, MAO inhibitors, pentoxifylline, propoxyphene, salicylates, and sulfonamide antibiotics may increase hypoglycemic effects
- Corticosteroids, danazol, diazoxide, diuretics, glucagon, isoniazid, estrogens, progestogens, niacin, phenothiazines, somatropin, sympathomimetic agents, and thyroid hormones may reduce blood glucose-lowering effects
- Beta-blockers, clonidine, and reserpine may mask or blunt the symptoms of hypoglycemia
Curated Content: Needs Vetting Before Put to Clinical Use