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ALIMENTARY TRACT AND METABOLISM › DRUGS USED IN DIABETES › INSULINS AND ANALOGUES › Insulins and analogues for injection, intermediate- or long-acting combined with fast-acting
insulin (beef)
A10AD02
Forms & Strengths
- U-40, U-80 beef insulin
- Regular beef insulin
- NPH beef insulin
- Lente beef insulin
- Ultralente beef insulin
Adult Dosing
- Initial dose 0.5-1 unit/kg/day
- Titrate dose based on glucose monitoring
- Premixed insulins: 0.5-1 unit/kg/day
- U-40, U-80: dose adjustment based on glucose levels
Pediatric Dosing
- Initial dose 0.25-0.5 unit/kg/day
- Titrate dose based on glucose monitoring
- Premixed insulins: 0.25-0.5 unit/kg/day
- Dose adjustment based on glucose levels and weight
Indications
- Type 1 diabetes mellitus
- Type 2 diabetes mellitus
- Diabetic ketoacidosis
- Hyperkalemia
- Hyperglycemia
Mechanism of Action
- Increases glucose uptake by cells
- Decreases glucose production in liver
- Increases glycogen synthesis
- Decreases lipolysis and ketogenesis
Contraindications
- Hypersensitivity to beef insulin or pork insulin
- Hypoglycemia
- Diabetic coma
Adverse Reactions
- Hypoglycemia
- Allergic reactions
- Lipodystrophy
- Local injection site reactions
- Weight gain
Drug Interactions
- Beta-blockers: may mask hypoglycemic symptoms
- Thiazides: may increase hyperglycemia
- Corticosteroids: may increase hyperglycemia
- Oral contraceptives: may affect glucose tolerance
Curated Content: Needs Vetting Before Put to Clinical Use