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ALIMENTARY TRACT AND METABOLISM › DRUGS USED IN DIABETES › INSULINS AND ANALOGUES › Insulins and analogues for injection, intermediate- or long-acting combined with fast-acting
insulin aspart
A10AD05
Forms & Strengths
- 100 units/mL solution for injection
- 3 mL pre-filled pen
- 10 mL vial
- 5x3 mL pre-filled pen pack
Adult Dosing
- 0.5-1 unit/kg/day SC in 2-4 divided doses
- titrate to achieve glucose control
- administer 5-10 minutes before meals
Pediatric Dosing
- 0.5-1 unit/kg/day SC in 2-4 divided doses for children 1-12 years old
- same dosing as adults for adolescents >12 years old
Indications
- Type 1 diabetes management
- Type 2 diabetes management
- diabetes management during pregnancy
Mechanism of Action
- rapid-acting human insulin analog
- regulates glucose metabolism and uptake
- reduces hepatic glucose production
Contraindications
- hypersensitivity to insulin aspart
- diabetic ketoacidosis (use IV regular insulin instead)
Adverse Reactions
- hypoglycemia
- injection site reactions
- lipodystrophy
- allergic reactions (rash, urticaria)
Drug Interactions
- beta-blockers may mask hypoglycemia symptoms
- ACE inhibitors increase risk of hypoglycemia
- salicylates and sulfonamides increase risk of hypoglycemia
Curated Content: Needs Vetting Before Put to Clinical Use