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ALIMENTARY TRACT AND METABOLISM › DRUGS USED IN DIABETES › INSULINS AND ANALOGUES › Insulins and analogues for injection, long-acting
insulin (human)
A10AE01
Forms & Strengths
- U-100 solution for injection
- U-100 suspension for injection
- U-50 solution for injection
- U-500 solution for injection
Adult Dosing
- Initial dose: 0.5-1 unit/kg/day
- Maintenance dose: 0.5-2 units/kg/day
- Adjust dose based on blood glucose monitoring
Pediatric Dosing
- Children >11 years: 0.5-1 unit/kg/day
- Children 6-11 years: 0.25-0.5 unit/kg/day
- Children 1-5 years: 0.2-0.4 unit/kg/day
- Infants <1 year: individualized dosing
Indications
- Type 1 diabetes mellitus
- Type 2 diabetes mellitus
- Diabetes during pregnancy
- Stress hyperglycemia
Mechanism of Action
- Stimulates glucose uptake in muscles and adipose tissue
- Inhibits glucose production in liver
- Regulates lipolysis and lipogenesis
Contraindications
- Hypersensitivity to insulin or excipients
- Diabetic ketoacidosis with mixed or unknown cause
Adverse Reactions
- Hypoglycemia
- Lipodystrophy
- Local injection site reactions
- Allergic reactions
- Weight gain
Drug Interactions
- Beta-blockers: may mask hypoglycemic symptoms
- Thiazides: may worsen glucose tolerance
- Salicylates: may increase hypoglycemic effect
- Oral contraceptives: may worsen glucose tolerance
- Warfarin: may alter INR
Curated Content: Needs Vetting Before Put to Clinical Use