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ALIMENTARY TRACT AND METABOLISM › DRUGS USED IN DIABETES › INSULINS AND ANALOGUES › Insulins and analogues for injection, long-acting
insulin detemir
A10AE05
Forms & Strengths
- Injection: 100 units/mL in 3 mL FlexTouch pen
- Injection: 100 units/mL in 3 mL PenFill cartridge
Adult Dosing
- Type 1 diabetes: Subcutaneously once or twice daily, individualized based on metabolic needs
- Type 2 diabetes: Subcutaneously 0.1 to 0.2 units/kg or up to 10 units once or twice daily
- Conversion from other basal insulins: Initial dose usually administered on a unit-to-unit basis
Pediatric Dosing
- Type 1 diabetes (children >=2 years): Subcutaneously once or twice daily, individualized
- Pediatric dosing must be calculated carefully based on current weight and blood glucose monitoring
Indications
- Improvement of glycemic control in adult and pediatric patients with type 1 diabetes mellitus
- Improvement of glycemic control in adult patients with type 2 diabetes mellitus
Mechanism of Action
- Long-acting human insulin analog produced by recombinant DNA technology
- Binds to insulin receptors, lowering blood glucose by facilitating cellular uptake of glucose
- Inhibits hepatic glucose production and stimulates lipogenesis while inhibiting lipolysis and proteolysis
- Fatty acid chain attachment promotes self-association and strong reversible binding to albumin, extending duration of action
Contraindications
- Hypoglycemia
- Hypersensitivity to insulin detemir or any of its excipients
Adverse Reactions
- Hypoglycemia
- Weight gain
- Injection site reactions (lipodystrophy, pruritus, rash)
- Allergic reactions and anaphylaxis
- Hypokalemia
Drug Interactions
- Antidiabetic agents, ACE inhibitors, disopyramide, fibrates, fluoxetine, MAOIs, pentoxifylline, propoxyphene, salicylates, and sulfonamides may increase hypoglycemia risk
- Atypical antipsychotics, corticosteroids, danazol, diuretics, estrogens, glucagon, isoniazid, niacin, oral contraceptives, phenothiazines, and sympathomimetics may decrease blood glucose-lowering effect
- Beta-blockers, clonidine, guanethidine, and reserpine may mask symptoms of hypoglycemia
Curated Content: Needs Vetting Before Put to Clinical Use