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ALIMENTARY TRACT AND METABOLISM › DRUGS USED IN DIABETES › BLOOD GLUCOSE LOWERING DRUGS, EXCL. INSULINS › Other blood glucose lowering drugs, excl. insulins
benfluorex
A10BX06
Forms & Strengths
- 150mg tablets
- Film-coated tablets
Adult Dosing
- 1 to 2 tablets per day
- Dose titration based on clinical response
Pediatric Dosing
- Not recommended for use in children
- Safety and efficacy not established in pediatric patients
Indications
- Treatment of type 2 diabetes mellitus
- Reduction of cardiovascular risk factors
Mechanism of Action
- Activates peroxisome proliferator-activated receptor gamma (PPARγ)
- Increases insulin sensitivity
- Decreases glucose production in the liver
Contraindications
- Hypersensitivity to benfluorex or any excipients
- Pregnancy and lactation
- Severe renal impairment
- Severe hepatic impairment
Adverse Reactions
- Headache
- Nausea and vomiting
- Abdominal pain
- Increased risk of valvular heart disease
Drug Interactions
- Warfarin: increased anticoagulant effect
- CYP2C9 substrates: potential for reduced efficacy
- Insulin secretagogues: increased risk of hypoglycemia
Curated Content: Needs Vetting Before Put to Clinical Use