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ALIMENTARY TRACT AND METABOLISM › VITAMINS › VITAMIN A AND D, INCL. COMBINATIONS OF THE TWO › Vitamin D and analogues
combinations
A11CC20
Forms & Strengths
- Oral tablets containing various combinations of Vitamin D and Calcium
- Chewable tablets containing Cholecalciferol (Vitamin D3) and Calcium Carbonate
- Oral capsules with fat-soluble vitamin combinations
- Liquid drops containing Vitamin D and related micronutrients
Adult Dosing
- Vitamin D3 / Calcium Carbonate: 1 to 2 tablets daily with meals or as directed by healthcare provider
- Therapeutic multivitamin/mineral combinations: 1 tablet daily
- Osteoporosis prevention: Calcium 1000-1200 mg combined with Vitamin D 800-1000 IU daily in divided doses
Pediatric Dosing
- Pediatric formulations depend on specific combination and age
- Vitamin D supplementation in infants: 400 IU daily as per pediatric guidelines
- Multivitamin with minerals pediatric drops: Dosages vary strictly by age and weight per pediatrician
Indications
- Prevention and treatment of calcium and vitamin D deficiency states
- Adjunct therapy in the prevention and treatment of osteoporosis
- Nutritional supplementation during pregnancy, lactation, and growth periods
- Supportive care for malabsorption syndromes associated with vitamin/mineral deficiencies
Mechanism of Action
- Vitamin D enhances intestinal absorption of calcium and phosphorus and promotes bone mineralization
- Calcium acts as a vital structural component of bone and plays essential roles in neuromuscular function and blood coagulation
- Combined micronutrients synergistically support metabolic homeostasis and enzymatic reactions
Contraindications
- Hypercalcemia and hypercalciuria
- Nephrolithiasis (kidney stones) involving calcium compounds
- Severe renal impairment or failure
- Hypervitaminosis D
- Known hypersensitivity to any component of the specific combination product
Adverse Reactions
- Constipation, flatulence, nausea, and abdominal discomfort
- Hypercalcemia and hypercalciuria with prolonged or high-dose usage
- Mild diarrhea or dyspepsia
- Allergic reactions (rash, pruritus) in sensitive individuals
Drug Interactions
- Decreased absorption of bisphosphonates, tetracyclines, and fluoroquinolones due to chelation with calcium
- Thiazide diuretics may increase the risk of hypercalcemia by reducing renal calcium excretion
- Cardiac glycosides (digoxin): Hypercalcemia increases the risk of fatal cardiac arrhythmias
- Systemic corticosteroids may reduce calcium absorption
Curated Content: Needs Vetting Before Put to Clinical Use