← Search & browse all drugs
ALIMENTARY TRACT AND METABOLISM › VITAMINS › OTHER PLAIN VITAMIN PREPARATIONS › Other plain vitamin preparations
pyridoxal phosphate
A11HA06
Forms & Strengths
- Tablets: 5mg, 10mg, 20mg, 25mg, 50mg
- Injectable solution: 100mg/mL
Adult Dosing
- Vitamin B6 deficiency: 50-100mg/day orally
- For homocystinuria: 100-300mg/day orally
- For pyridoxine-dependent seizures: 50-100mg/day orally
Pediatric Dosing
- Neonates: 0.2-0.5mg/day orally
- Infants 1-12 months: 0.2-1.0mg/day orally
- Children 1-12 years: 1.0-2.0mg/day orally
Indications
- Treatment of vitamin B6 deficiency
- Homocystinuria
- Pyridoxine-dependent seizures
- Sideroblastic anemia
Mechanism of Action
- Cofactor for numerous enzyme reactions
- Involved in synthesis of neurotransmitters
- Necessary for hemoglobin synthesis
Contraindications
- Hypersensitivity to pyridoxal phosphate or any component of the formulation
- Leber's optic neuropathy
Adverse Reactions
- Numbness or tingling of hands and feet
- Sensitivity to sunlight
- Allergic reactions
- Gastrointestinal upset
Drug Interactions
- Reduced efficacy of levodopa when used concomitantly
- Increased risk of neuropathy with isoniazid
- Interference with laboratory tests for urinary urobilinogen
Curated Content: Needs Vetting Before Put to Clinical Use