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dexpanthenol

A11HA30

Forms & Strengths

Injectable solution: 250 mg/mL
Oral tablets: 50 mg, 100 mg
Topical cream/ointment: 2% to 5%

Adult Dosing

Postoperative intestinal atony/paralytic ileus: 250 mg to 500 mg IM, repeated in 2 hours, then every 4 to 6 hours as needed
Topical dermatitis/wounds: Apply thin layer to affected area 1 to 3 times daily

Pediatric Dosing

Paralytic ileus (off-label): 10 to 25 mg/kg IM administered every 6 to 12 hours as clinically indicated
Topical dermatitis: Apply thin layer to affected skin 1 to 3 times daily

Indications

Prevention and treatment of postoperative distention and intestinal atony
Paralytic ileus
Topical adjunctive treatment of minor skin wounds, abrasions, and diaper dermatitis

Mechanism of Action

Alcohol derivative of pantothenic acid (Vitamin B5)
Converted in the body to pantothenic acid, which is an essential component of coenzyme A (CoA)
CoA is critical for acetylation reactions, gluconeogenesis, steroid synthesis, and porphyrin synthesis, thereby enhancing peristalsis and mucosal regeneration

Contraindications

Hemophilia (due to potential prolonged bleeding time with parenteral use)
Mechanical ileus or bowel obstruction
Hypersensitivity to dexpanthenol or any component of the formulation

Adverse Reactions

Allergic contact dermatitis (topical use)
Pruritus and erythema
Rare parenteral reactions: vomiting, diarrhea, agitation, and transient drop in blood pressure

Drug Interactions

Succinylcholine: Dexpanthenol may prolong the neuromuscular blocking effects of succinylcholine (avoid administration within 1 hour of succinylcholine)
Antibiotics: May decrease absorption or alter efficacy when used concurrently with certain oral antibiotics affecting gut flora

Curated Content: Needs Vetting Before Put to Clinical Use