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ALIMENTARY TRACT AND METABOLISM › MINERAL SUPPLEMENTS › CALCIUM › Calcium
calcium lactate
A12AA05
Forms & Strengths
- Oral tablets: 325 mg
- Oral tablets: 650 mg
- Oral powder
Adult Dosing
- Calcium deficiency: 325 mg to 650 mg orally 2 to 3 times daily with meals
- Hyperphosphatemia in chronic kidney disease: 1.5 g to 3 g orally with meals, titrated to serum phosphate levels
Pediatric Dosing
- Neonatal hypocalcemia: 400 mg/kg/day to 800 mg/kg/day orally divided in 4 to 6 doses
- Calcium deficiency / supplementation: 400 mg/kg/day to 500 mg/kg/day orally divided into 3 to 4 doses
Indications
- Prevention and treatment of calcium deficiency states
- Adjunctive treatment of hypocalcemia (e.g., tetany, hypoparathyroidism)
- Hyperphosphatemia management in chronic kidney disease
Mechanism of Action
- Provides elemental calcium to maintain serum calcium concentrations, essential for nervous system, muscular, and skeletal function
- Acts as a phosphate binder in the gastrointestinal tract by precipitating insoluble calcium phosphate, reducing dietary phosphate absorption
Contraindications
- Hypercalcemia
- Hypercalciuria and severe renal calculi
- Ventricular fibrillation during cardiac resuscitation
- Known hypersensitivity to calcium salts or excipients
Adverse Reactions
- Constipation
- Nausea and vomiting
- Abdominal pain and flatulence
- Hypercalcemia (with chronic high doses or renal impairment)
- Hypercalciuria and nephrolithiasis
Drug Interactions
- Decreases absorption of oral tetracyclines, fluoroquinolones, iron, and ketoconazole through chelation
- Thiazide diuretics decrease renal calcium excretion, increasing risk of hypercalcemia
- Systemic corticosteroids decrease calcium absorption
- Cardiac glycosides (digoxin) may cause cardiac arrhythmias if hypercalcemia occurs
Curated Content: Needs Vetting Before Put to Clinical Use