← Search & browse all drugs
ALIMENTARY TRACT AND METABOLISM › MINERAL SUPPLEMENTS › CALCIUM › Calcium
calcium glycerylphosphate
A12AA08
Forms & Strengths
- Oral tablet: 200 mg
- Oral powder: various concentrations in combination products
- Oral liquid: various concentrations in combination products
Adult Dosing
- Calcium supplementation: 200 mg to 400 mg elemental calcium equivalent orally 1 to 3 times daily with meals
- Phosphate/Calcium balancing in hypophosphatemia or hypocalcemia: individualized based on serum levels
Pediatric Dosing
- Safety and efficacy not well established in pediatric populations
- Pediatric dosing must be individualized based on age, weight, and serum calcium/phosphate concentrations under physician supervision
Indications
- Prevention and treatment of calcium deficiency states
- Dietary supplement for states with increased calcium and phosphate requirements
- Adjunctive therapy in osteoporosis or osteomalacia management
Mechanism of Action
- Provides elemental calcium essential for maintaining the integrity of nervous, muscular, and skeletal systems
- Provides glycerophosphate moiety acting as a source of phosphate ions necessary for cellular energy transfer, bone mineralization, and buffer systems
Contraindications
- Hypercalcemia (e.g., from hyperparathyroidism, vitamin D overdose, malignant tumors)
- Hypercalciuria and severe renal failure
- Nephrolithiasis (kidney stones composed of calcium salts)
- Hypophosphatemia accompanied by high serum calcium (relative contraindication)
- Known hypersensitivity to calcium salts or glycerophosphate derivatives
Adverse Reactions
- Constipation
- Flatulence
- Nausea
- Gastric upset
- Hypercalcemia (with prolonged use or high doses)
- Hypercalciuria
Drug Interactions
- Thiazide diuretics: decrease renal calcium excretion, increasing risk of hypercalcemia
- Systemic corticosteroids: decrease calcium absorption
- Tetracyclines and fluoroquinolones: oral calcium forms insoluble chelate complexes, decreasing antibiotic absorption (separate administration by at least 2 to 4 hours)
- Cardiac glycosides (digoxin): high extracellular calcium levels can precipitate cardiac arrhythmias
- Iron salts: calcium decreases iron absorption when administered concomitantly
Curated Content: Needs Vetting Before Put to Clinical Use