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ALIMENTARY TRACT AND METABOLISM › MINERAL SUPPLEMENTS › OTHER MINERAL SUPPLEMENTS › Zinc
zinc protein complex
A12CB03
Forms & Strengths
- Oral capsules/tablets: variable elemental zinc content based on complex (check product labeling)
Adult Dosing
- Zinc deficiency: 15-50 mg elemental zinc daily, adjusted based on serum levels
- Adjuvant therapy (e.g., diarrhea): 10-20 mg elemental zinc daily
Pediatric Dosing
- Zinc deficiency: 0.5-1 mg/kg/day elemental zinc, divided
- Acute diarrhea (WHO guideline > 6 months): 20 mg elemental zinc daily for 10-14 days
- Acute diarrhea (WHO guideline < 6 months): 10 mg elemental zinc daily for 10-14 days
Indications
- Treatment and prevention of zinc deficiency
- Adjunctive treatment of acute childhood diarrhea
Mechanism of Action
- Provides essential trace element required for catalytic activity of numerous enzymes
- Supports immune function, protein synthesis, wound healing, DNA synthesis, and cell division
Contraindications
- Hypersensitivity to zinc or any component of the formulation
- Acute renal failure (may lead to accumulation)
Adverse Reactions
- Nausea
- Vomiting
- Epigastric pain
- Diarrhea (with high doses)
- Copper deficiency with chronic high-dose use (leading to anemia and neutropenia)
Drug Interactions
- Fluoroquinolones and tetracyclines: decreased antibiotic absorption due to chelation
- Penicillamine: decreased absorption and increased excretion of zinc
- Iron and calcium supplements: may decrease zinc absorption when taken concurrently
Curated Content: Needs Vetting Before Put to Clinical Use