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ALIMENTARY TRACT AND METABOLISM › MINERAL SUPPLEMENTS › OTHER MINERAL SUPPLEMENTS › Magnesium
magnesium gluconate
A12CC03
Forms & Strengths
- Tablets: 500mg
- Injection: 10% (1g/10mL), 20% (2g/10mL)
- Oral solution: 54mg/5mL
Adult Dosing
- Prophylaxis of magnesium deficiency: 500mg orally daily
- Treatment of magnesium deficiency: 1-2g IV or orally every 6 hours
- Severe pre-eclampsia or eclampsia: 4-6g IV loading dose followed by 2g/hour
Pediatric Dosing
- Neonatal hypocalcemia: 100-200mg/kg/day IV divided every 6-12 hours
- Pediatric magnesium deficiency: 10-20mg/kg/day orally divided every 6-8 hours
Indications
- Magnesium deficiency
- Severe pre-eclampsia or eclampsia
- Hypocalcemia
- Cardiac arrhythmias
- Bronchial asthma
Mechanism of Action
- Involves regulation of ion channels and cell signaling pathways
- Increases intracellular magnesium levels
- Antagonizes calcium channels
Contraindications
- Severe renal impairment
- Myasthenia gravis
- Pregnancy category: C
Adverse Reactions
- Nausea
- Vomiting
- Diarrhea
- Flushing
- Muscle weakness
Drug Interactions
- Quinidine: may potentiate cardiac effects
- Digoxin: may increase risk of digitalis toxicity
- Antibiotics: may decrease absorption
- Bisphosphonates: may decrease absorption
Curated Content: Needs Vetting Before Put to Clinical Use