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ALIMENTARY TRACT AND METABOLISM › OTHER ALIMENTARY TRACT AND METABOLISM PRODUCTS › OTHER ALIMENTARY TRACT AND METABOLISM PRODUCTS › Amino acids and derivatives
ademetionine
A16AA02
Forms & Strengths
- Tablets (enteric-coated): 200 mg, 400 mg, 500 mg
- Powder and solvent for solution for injection: 500 mg
Adult Dosing
- Intrahepatic cholestasis: Oral 800 mg to 1600 mg daily in divided doses
- Intrahepatic cholestasis (IV/IM): 500 mg to 1000 mg daily for up to 2 weeks
- Depression: Oral 800 mg to 1600 mg daily in divided doses
Pediatric Dosing
- Safety and efficacy not established in pediatric patients; use not generally recommended
Indications
- Intrahepatic cholestasis in pre-cirrhotic conditions
- Intrahepatic cholestasis of pregnancy
- Depressive symptoms (in various regions)
Mechanism of Action
- Acts as a methyl group donor and precursor to physiological sulfated compounds (cysteine, taurine, glutathione)
- Restores hepatic transmethylation and transsulfuration pathways, membrane fluidity, and hepatocyte function
- Influences neurotransmitter synthesis and monoamine turnover in the central nervous system
Contraindications
- Genetic defects affecting methionine metabolism and/or causing homocystinuria and/or hyperhomocysteinemia
- Known hypersensitivity to ademetionine or excipients
- Bipolar disorder (risk of precipitating manic episodes)
Adverse Reactions
- Nausea, abdominal pain, diarrhea, dry mouth
- Headache, dizziness, insomnia, anxiety
- Asthenia, urinary tract infections
- Injection site reactions (pain, rash)
Drug Interactions
- Antidepressants (SSRIs, tricyclics, MAOIs): Potential risk of serotonin syndrome or CNS overstimulation
- Levodopa: May decrease the efficacy of levodopa
- Coadministration with other methionine-containing products or precursors
Curated Content: Needs Vetting Before Put to Clinical Use