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pegzilarginase

A16AB24

Forms & Strengths

for injection: 20 mg/2 mL (10 mg/mL) single-dose vial

Adult Dosing

initial dose: 0.07 mg/kg IV over 30 minutes
maintenance dose: 0.07 mg/kg IV over 30 minutes every 2 weeks

Pediatric Dosing

not established

Indications

treatment of adult patients with late-stage arginase deficiency

Mechanism of Action

recombinant arginase enzyme that reduces plasma arginine levels by hydrolyzing arginine to ornithine and urea

Contraindications

none known

Adverse Reactions

injection site reactions
nausea
vomiting
abdominal pain
increased blood urea nitrogen

Drug Interactions

may reduce plasma levels of arginine-containing medications

Curated Content: Needs Vetting Before Put to Clinical Use