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ALIMENTARY TRACT AND METABOLISM › OTHER ALIMENTARY TRACT AND METABOLISM PRODUCTS › OTHER ALIMENTARY TRACT AND METABOLISM PRODUCTS › Various alimentary tract and metabolism products
telotristat
A16AX15
Forms & Strengths
- Telotristat ethyl 250 mg tablets
Adult Dosing
- 250 mg orally three times daily with food
- Administer in combination with somatostatin analog (SSA) therapy
Pediatric Dosing
- Safety and efficacy in pediatric patients have not been established
Indications
- Treatment of carcinoid syndrome-induced diarrhea in combination with somatostatin analog therapy in adults inadequately controlled by SSA therapy
Mechanism of Action
- Peripherally restricted tryptophan hydroxylase inhibitor
- Reduces the rate of peripheral serotonin synthesis, thereby decreasing carcinoid syndrome-associated diarrhea
Contraindications
- Hypersensitivity to telotristat or any components of the formulation
Adverse Reactions
- Nausea
- Headache
- Increased gamma-glutamyltransferase (GGT)
- Depression
- Flatulence
- Decreased appetite
- Peripheral edema
- Pyrexia
Drug Interactions
- CYP2B6 substrates: telotristat may decrease exposure of co-administered CYP2B6 substrates (e.g., methadone)
- Monitor for reduced efficacy of concomitant narrow therapeutic index drugs metabolized by CYP2B6
Curated Content: Needs Vetting Before Put to Clinical Use