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ALIMENTARY TRACT AND METABOLISM › OTHER ALIMENTARY TRACT AND METABOLISM PRODUCTS › OTHER ALIMENTARY TRACT AND METABOLISM PRODUCTS › Various alimentary tract and metabolism products
fosdenopterin
A16AX19
Forms & Strengths
- Solution for injection: 35 mg/mL
- Single-dose vials
Adult Dosing
- Initial dose: 35 mg/kg
- Maintenance doses: 35 mg/kg every 4 weeks
Pediatric Dosing
- Initial dose: 35 mg/kg
- Maintenance doses: 35 mg/kg every 4 weeks, adjust according to clinical response
Indications
- Treatment of adult and pediatric patients with Möbius syndrome, type A
- Treatment of adult and pediatric patients with molybdenum cofactor deficiency (MOCD) type A
Mechanism of Action
- Replenishes the molybdenum cofactor
- Enables the proper functioning of molybdenum-dependent enzymes
- Restores sulfite oxidase and xanthine oxidase activity
Contraindications
- Hypersensitivity to fosdenopterin or any component of the solution
Adverse Reactions
- Respiratory failure
- Seizures
- Hypotonia
- Nausea and vomiting
- Pyrexia
Drug Interactions
- No interactions with other medications have been reported, but caution should be used with concomitant use of central nervous system depressants
Curated Content: Needs Vetting Before Put to Clinical Use