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BLOOD AND BLOOD FORMING ORGANS › ANTITHROMBOTIC AGENTS › ANTITHROMBOTIC AGENTS › Platelet aggregation inhibitors excl. heparin
combinations
B01AC30
Forms & Strengths
- Tablets: 81 mg aspirin and 40 mg lysine acetylsalicylate
- Tablets: 162 mg aspirin and 80 mg lysine acetylsalicylate
- Effervescent tablets: 500 mg acetylsalicylic acid and 9 mg lysine acetylsalicylate
- Suppositories: 500 mg acetylsalicylic acid and 50 mg lysine acetylsalicylate
Adult Dosing
- Low-dose aspirin: 75-100 mg/day for cardiovascular protection
- Anti-inflammatory: 500-1000 mg every 4-6 hours
- Pain relief: 325-1000 mg every 4-6 hours
Pediatric Dosing
- Not recommended for children under 16 years due to risk of Reye's syndrome
- For pain and inflammation in children over 16: 500-1000 mg every 4-6 hours
Indications
- Prophylaxis of myocardial infarction
- Prophylaxis of ischemic stroke
- Relief of pain and inflammation in conditions like arthritis
- Reduction of fever
Mechanism of Action
- Inhibition of cyclooxygenase enzymes COX-1 and COX-2
- Decreased production of prostaglandins and thromboxane
- Anti-inflammatory and antiplatelet effects
Contraindications
- Hypersensitivity to aspirin or other NSAIDs
- Active peptic ulcer disease
- Bleeding disorders
- Children with varicella or influenza-like illness due to risk of Reye's syndrome
Adverse Reactions
- Gastrointestinal upset and bleeding
- Allergic reactions such as rash and urticaria
- Renal impairment
- Reye's syndrome in children
Drug Interactions
- Increased risk of bleeding with anticoagulants like warfarin
- Interaction with ACE inhibitors and diuretics to reduce antihypertensive effect
- Enhanced hypoglycemic effect when used with oral antidiabetic agents
Curated Content: Needs Vetting Before Put to Clinical Use