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adrenalone

B02BC05

Forms & Strengths

Ophthalmic solution 1%
Topical solution 0.1% - 1%

Adult Dosing

Topical hemostasis: Apply 1% solution to bleeding mucosal surfaces as needed
Ophthalmic: Instill 1 to 2 drops into the affected eye(s) 1 to 4 times daily

Pediatric Dosing

Safety and efficacy not established in pediatric patients; use generally avoided or restricted to specialist oversight

Indications

Control of superficial capillary bleeding in surgery and dentistry
Temporary reduction of conjunctival hyperemia

Mechanism of Action

Direct-acting alpha-1 and beta-adrenergic receptor agonist causing vasoconstriction of superficial blood vessels

Contraindications

Hypersensitivity to adrenalone or other sympathomimetics
Angle-closure glaucoma or risk thereof (for ophthalmic use)
Severe hypertension or advanced cardiovascular disease

Adverse Reactions

Transient stinging or burning upon application
Reactive hyperemia ("rebound congestion") with prolonged use
Mydriasis
Systemic sympathomimetic effects (rare: tachycardia, palpitations, headache, hypertension)

Drug Interactions

Monoamine oxidase inhibitors (MAOIs): May precipitate severe hypertensive crisis
Tricyclic antidepressants: May potentiate the pressor response of sympathomimetics
Beta-blockers: May lead to severe peripheral vasoconstriction and hypertension

Curated Content: Needs Vetting Before Put to Clinical Use