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thrombin

B02BC06

Forms & Strengths

Topical powder for solution: 1,000 IU
Topical powder for solution: 5,000 IU
Topical powder for solution: 10,000 IU
Topical powder for solution: 20,000 IU
Topical solution: 1,000 IU/mL

Adult Dosing

Topical application: 1,000 IU to 2,000 IU per site depending on bleeding severity
Can be used in conjunction with a sterile gelatin sponge
Apply directly to the bleeding surface as a solution or powder

Pediatric Dosing

Topical application: Safety and efficacy not formally established in neonates
Use lowest effective volume and concentration based on body surface area in children

Indications

Aid to hemostasis in procedures involving capillary and small venule bleeding
Adjunct in surgical procedures where standard hemostatic techniques are ineffective or impractical

Mechanism of Action

Catalyzes the conversion of fibrinogen to fibrin
Promotes localized blood clot formation at the site of topical application

Contraindications

Known hypersensitivity to thrombin or any component of the formulation
Do not inject intravascularly due to risk of severe systemic thrombosis and disseminated intravascular coagulation (DIC)

Adverse Reactions

Allergic reactions including anaphylaxis with repeat exposure
Development of antibodies against human or bovine thrombin
Paradoxical hemorrhage due to consumption of clotting factors (systemic absorption)

Drug Interactions

Topical products applied to the site may be inactivated by strong oxidizing agents or iodine
Systemic procoagulant risk increases if co-administered with systemic hemostatic agents

Curated Content: Needs Vetting Before Put to Clinical Use