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BLOOD AND BLOOD FORMING ORGANS › ANTIHEMORRHAGICS › VITAMIN K AND OTHER HEMOSTATICS › Blood coagulation factors
coagulation factor X
B02BD13
Forms & Strengths
- Powder for injection 20 mg/vial
- Powder for injection 40 mg/vial
- Powder for injection 60 mg/vial
Adult Dosing
- Dose is individualized and based on coagulation factor X levels
- Typical dosage is 20-40 mg per dose
- Repeat dosing every 24 hours as needed
Pediatric Dosing
- Similar to adult dosing, based on coagulation factor X levels
- Lower doses may be required due to increased sensitivity
- Maximum dose 40 mg per dose
Indications
- Treatment and prevention of bleeding due to Factor X deficiency
- Treatment of bleeding due to Factor VII deficiency with concurrent Factor X deficiency
- Perioperative management of bleeding in patients with Factor X deficiency
Mechanism of Action
- Coagulation Factor X is a vitamin K-dependent enzyme
- Activates prothrombin to thrombin in the coagulation cascade
- Essential for blood clot formation
Contraindications
- Known hypersensitivity to coagulation Factor X or any component of the formulation
- Disseminated intravascular coagulation
- Active thrombophlebitis or thromboembolic disorders
Adverse Reactions
- Allergic reactions, including anaphylaxis
- Thrombosis and thromboembolic events
- Coagulation inhibitor formation
Drug Interactions
- May increase the risk of thrombosis with concomitant use of oral or parenteral estrogens
- May enhance the anticoagulant effect of warfarin
- May be affected by the concomitant use of antifibrinolytic agents
Curated Content: Needs Vetting Before Put to Clinical Use