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BLOOD AND BLOOD FORMING ORGANS › ANTIANEMIC PREPARATIONS › IRON PREPARATIONS › Iron trivalent, oral preparations
sodium feredetate
B03AB03
Forms & Strengths
- Injectable solution: 2 mL ampoules of 30.4 mg iron per mL
- Injectable solution: 2 mL ampoules of 10.2 mg iron per 2 mL
- Injectable solution: 10 mL vials of 30.4 mg iron per mL
Adult Dosing
- 12.5 mg iron IV daily, for up to 10 days
- Total cumulative dose not to exceed 62.5 mg iron
- Administer by slow IV injection over 1-2 minutes
Pediatric Dosing
- 5-10 mg iron IV daily, for up to 5 days, for infants and children
- Not recommended for children under 4 months old
- Pediatric dosing regimens may require adjustment based on patient weight
Indications
- Treatment of iron-deficiency anemia in adults and children
- Prophylaxis against iron deficiency in pregnancy
- Treatment of iron deficiency where oral iron is ineffective, not tolerated, or in certain cases of malabsorption
Mechanism of Action
- Replenishes iron stores in the body, correcting iron deficiency anemia
- Iron from sodium feredetate is utilized in the production of hemoglobin
- Rapid increase in circulating iron, corrected anemia
Contraindications
- Known hypersensitivity to sodium feredetate or any component of the formulation
- Hemochromatosis, hemosiderosis, or other iron overload conditions
- Pregnancy, especially during the first trimester, except in cases of documented iron deficiency anemia
Adverse Reactions
- Cardiovascular system: hypotension
- Central nervous system: headache, dizziness
- Gastrointestinal system: nausea, abdominal pain
- Skin: pruritus, rash, urticaria
Drug Interactions
- Concurrent use with antihypertensive agents: increased risk of hypotension
- Interference with certain laboratory tests (e.g., serum calcium): spurious results
Curated Content: Needs Vetting Before Put to Clinical Use