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BLOOD AND BLOOD FORMING ORGANS › ANTIANEMIC PREPARATIONS › IRON PREPARATIONS › Iron in combination with folic acid
ferric oxide polymaltose complexes and folic acid
B03AD04
Forms & Strengths
- Oral capsules
- Ferric oxide polymaltose complexes 50-100 mg iron
- Folic acid 0.25-0.5 mg
- Tablets
- Ferric oxide polymaltose complexes 100-200 mg iron
- Folic acid 0.5-1 mg
Adult Dosing
- Ferrous deficiency anemia: 1-2 capsules or tablets per day
- Pregnancy: 1 capsule or tablet per day
- For iron deficiency prophylaxis: 1 capsule or tablet per day
Pediatric Dosing
- Infants and children: dosage based on iron requirements and patient weight
- Children under 12: typically half the adult dose
- Infants: 1-2 mg/kg of elemental iron per day
Indications
- Treatment of iron deficiency anemia
- Prophylaxis of iron deficiency anemia in pregnancy
- Prevention of iron deficiency in infants and toddlers
Mechanism of Action
- Ferric oxide polymaltose complexes release iron in the GI tract
- Iron then binds to transferrin and gets distributed to tissues
- Folic acid participates in erythropoiesis as a cofactor in DNA synthesis
- Folic acid reduces homocysteine levels, improving vascular health
Contraindications
- Hypersensitivity to iron, folic acid, or polymaltose
- Chronic hemolytic anemia without iron deficiency
- G6PD deficiency
- Acute gastrointestinal hemorrhage
Adverse Reactions
- Gastrointestinal upset, nausea, and diarrhea
- Constipation and dark stools due to iron
- Headache and dizziness
- Allergic reactions with rashes, pruritus, and anaphylaxis
Drug Interactions
- Tetracyclines: reduce iron absorption
- Quinolones: decrease iron bioavailability
- Vitamin E and tea: inhibit iron absorption
- Antacids: decrease iron absorption by increasing pH
Curated Content: Needs Vetting Before Put to Clinical Use