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BLOOD AND BLOOD FORMING ORGANS › ANTIANEMIC PREPARATIONS › OTHER ANTIANEMIC PREPARATIONS › Other antianemic preparations
daprodustat
B03XA07
Forms & Strengths
- Oral tablets: 1 mg, 2 mg, 4 mg
- Film-coated for oral administration
Adult Dosing
- Initially 2 mg or 4 mg orally once daily
- Titrate by 1 mg to 2 mg increments every 2 weeks as necessary
- Maximum dose 7 mg daily
Pediatric Dosing
- Safety and efficacy not established in patients under 18 years old
Indications
- Anemia associated with chronic kidney disease (CKD) in adult patients on dialysis
- Anemia associated with CKD in adult patients not on dialysis
Mechanism of Action
- Selective small molecule inhibitor of hypoxia-inducible factor prolyl hydroxylase
- Increases erythropoietin production and subsequently red blood cell count
Contraindications
- Hypersensitivity to daprodustat
Adverse Reactions
- Hypertension
- Hyperkalemia
- Diarrhea
- Headache
- Fatigue
Drug Interactions
- Concomitant strong CYP3A4 inducers may decrease daprodustat efficacy
- Avoid concomitant use of strong CYP3A4 inhibitors
Curated Content: Needs Vetting Before Put to Clinical Use