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protein hydrolysates

B05BA04

Forms & Strengths

Intravenous injection or infusion solution
Concentrate for solution for infusion (5%, 10%)
Ready-to-use solution for infusion (2.5%, 5%)

Adult Dosing

1.5-3.5 g protein/kg body weight/24h
Infusion rates should not exceed 0.1-0.2 g protein/kg body weight/hour
Typical volume of infusion solution: 1000-2000 mL/24h

Pediatric Dosing

1.5-3.0 g protein/kg body weight/24h for children >1 year
2.0-3.5 g protein/kg body weight/24h for infants <1 year
Infusion rates should be lower in children and infants due to their limited ability to metabolize

Indications

Protein substitution in conditions requiring parenteral nutrition
Severe catabolic states (e.g., severe injuries, infections, post-operatively)
Protein malnutrition or deficiency

Mechanism of Action

Provides essential amino acids and nitrogen to support protein synthesis
Serves as building blocks for tissue repair and maintenance
Enhances immune function and helps maintain fluid balance

Contraindications

Known hypersensitivity to protein hydrolysates or any component
Severe renal impairment without proper monitoring and dose adjustment
Unstable or severe metabolic disorders (e.g., hyperchloremic acidosis)

Adverse Reactions

Allergic reactions (e.g., anaphylaxis, rash, urticaria)
Fluid overload or electrolyte imbalance
Metabolic acidosis or disturbances in electrolyte balance
Hypersensitivity reactions (e.g., nausea, vomiting, diarrhea)

Drug Interactions

Other intravenous solutions or medications may interact and affect the stability of the protein hydrolysate solution
Concomitant administration with other high-osmolarity solutions may increase the risk of adverse effects
Interference with laboratory tests (e.g., electrolyte levels, urea, and glucose)

Curated Content: Needs Vetting Before Put to Clinical Use