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chlorhexidine

B05CA02

Forms & Strengths

Urethral Gel: 0.05% chlorhexidine gluconate in 0.75% hydroxyethylcellulose
Irrigation Solution: 0.02% w/v aqueous solution

Adult Dosing

Urethral Irrigation/Lubrication: Instill sufficient gel into the urethra prior to catheterization or cystoscopy.
Bladder Irrigation: 0.02% solution used for continuous or intermittent irrigation during urological procedures.

Pediatric Dosing

Safety and efficacy in pediatric patients have not been firmly established for urological/urethral gel formulations; use with caution.

Indications

Lubrication and disinfection of the urethra prior to catheterization, cystoscopy, or other urological procedures.
Prophylaxis against urinary tract infections associated with catheterization.

Mechanism of Action

Cationic molecule binds to negatively charged bacterial cell walls, causing disruption of the cytoplasmic membrane, leakage of intracellular constituents, and precipitation of cellular contents.

Contraindications

Hypersensitivity to chlorhexidine or any component of the formulation
Not for systemic or intravenous use
Avoid contact with meninges, brain tissue, and the inner ear

Adverse Reactions

Urethral irritation, burning, or stinging upon instillation
Allergic contact dermatitis and hypersensitivity reactions, including rare instances of anaphylaxis

Drug Interactions

Incompatible with anionic surfactants, soaps, and other oxidizing agents
Reduced antimicrobial efficacy in the presence of organic matter (blood, serum, pus)

Curated Content: Needs Vetting Before Put to Clinical Use