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BLOOD AND BLOOD FORMING ORGANS › BLOOD SUBSTITUTES AND PERFUSION SOLUTIONS › I.V. SOLUTION ADDITIVES › Amino acids
arginine hydrochloride
B05XB01
Forms & Strengths
- Injectable solution: 10% and 15% (100 mg/mL and 150 mg/mL) arginine hydrochloride
- Injectable solution: 10% (1000 mg/10 mL) arginine hydrochloride single-dose vials
- Injectable solution: 15% (1500 mg/10 mL) arginine hydrochloride single-dose vials
Adult Dosing
- Diagnostic aid for hepatic function: 9 g (as arginine hydrochloride) IV, over 45-60 minutes, once
- Metabolic alkalosis due to ammonium ion excess: 10-15 g (as arginine hydrochloride), IV, over 3-4 hours, up to 500 mL/day
- Hepatic encephalopathy treatment as adjunct: 250 mL of 10% arginine hydrochloride solution IV, 3 times daily
Pediatric Dosing
- No established pediatric dosing
- Use with caution, as pediatric dosing not established
- Limited information available, seek expert advice before use
Indications
- Diagnostic aid in the assessment of pituitary function
- Management of severe metabolic alkalosis due to ammonium ion excess
- Treatment as adjunct in hepatic encephalopathy
- Nutritional supplement for severe burns, sepsis, and trauma
Mechanism of Action
- Arginine hydrochloride works as an ammonia scavenger to treat metabolic alkalosis
- Stimulates the release of growth hormone
- Provides a source of the non-essential amino acid, arginine
Contraindications
- Hypersensitivity to arginine
- Hyperchloremic acidosis
- Eclampsia
- Severe kidney disease
Adverse Reactions
- Hypotension
- Bradycardia
- Abnormal ECG
- Nausea and vomiting
- Elevations of AST, ALT
Drug Interactions
- May interact with blood thinners (e.g., heparin, warfarin) due to increased risk of bleeding
- Potential interactions with medications used to treat diabetes
- Cautious use with medications that affect blood pressure
Curated Content: Needs Vetting Before Put to Clinical Use