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BLOOD AND BLOOD FORMING ORGANS › OTHER HEMATOLOGICAL AGENTS › OTHER HEMATOLOGICAL AGENTS › Enzymes
fibrinolysin and desoxyribonuclease
B06AA02
Forms & Strengths
- Fibrinolysin 1000 IU/ml, desoxyribonuclease 0.5 mg/ml solution for injection
- Fibrinolysin 5000 IU/ml, desoxyribonuclease 2.5 mg/ml solution for injection
Adult Dosing
- 1-2 ml (1000-2000 IU fibrinolysin, 0.5-1 mg desoxyribonuclease) by local injection
- Dosing may be repeated as necessary
Pediatric Dosing
- Not established
- Use in children is not recommended due to limited data
Indications
- Debridement of wounds and ulcers
- Treatment of abscesses and hematomas
- Removal of clots and blood from body cavities
Mechanism of Action
- Fibrinolysin degrades fibrin clots
- Desoxyribonuclease degrades DNA from necrotic cells and bacteria
Contraindications
- Known hypersensitivity to components
- Active bleeding or risk of bleeding
- Intravascular injection
Adverse Reactions
- Pain at injection site
- Infection
- Allergic reactions (e.g., anaphylaxis, rash)
Drug Interactions
- Anticoagulants (e.g., warfarin, heparin) may increase bleeding risk
- Fibrinolysin may inactivate aminocaproic acid
Curated Content: Needs Vetting Before Put to Clinical Use