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BLOOD AND BLOOD FORMING ORGANS › OTHER HEMATOLOGICAL AGENTS › OTHER HEMATOLOGICAL AGENTS › Enzymes
desoxyribonuclease
B06AA10
Forms & Strengths
- Inhalation solution: 1.0-2.5 mg/mL
- Injection: 1-2 mg/mL
Adult Dosing
- For inhalation: 1-2.5 mg/dose, 2-3 times a day
- For injection: 0.5-2 mg/kg/day, every 8-12 hours
Pediatric Dosing
- For inhalation: 0.5-2.5 mg/dose, 2-3 times a day
- For injection: 0.25-1 mg/kg/dose, every 6-12 hours
Indications
- Cystic fibrosis
- Atelectasis
- Mucoid impaction
- Postoperative respiratory therapy
Mechanism of Action
- Breakdown of extracellular DNA in sputum
- Hydrolysis of DNA into oligonucleotides
- Reduction of sputum viscosity
Contraindications
- Hypersensitivity to desoxyribonuclease
- Active bleeding
Adverse Reactions
- Pharyngitis
- Cough
- Dyspnea
- Chronic inflammation
- Increased risk of infection
Drug Interactions
- Acetylcysteine: increased risk of inactivation
- Pulmozyme: increased risk of inactivation
Curated Content: Needs Vetting Before Put to Clinical Use