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BLOOD AND BLOOD FORMING ORGANS › OTHER HEMATOLOGICAL AGENTS › OTHER HEMATOLOGICAL AGENTS › Enzymes
streptokinase, combinations
B06AA55
Forms & Strengths
- Powder for solution for injection/infusion, variable strengths containing streptokinase combined with other enzymes (e.g., streptodornase) based on specific regional products.
Adult Dosing
- Dosing is highly dependent on the specific combination product and clinical indication (e.g., enzymatic debridement of wounds, dissolution of clots).
- Refer to specific local product labeling for exact reconstitution and administration protocols.
Pediatric Dosing
- Safety and efficacy in pediatric patients have not been established.
- Use is generally avoided unless specific institutional protocols exist for severe localized indications.
Indications
- Enzymatic debridement of necrotic tissue, infected wounds, ulcers, and superficial hematomas (for combination preparations containing streptokinase and streptodornase).
Mechanism of Action
- Streptokinase acts as a thrombolytic agent by complexing with plasminogen to convert it into active plasmin, leading to fibrinolysis.
- Streptodornase is a deoxyribonuclease that liquefies purulent exudates and nucleoprotein debris in necrotic tissue, reducing viscosity.
Contraindications
- Known hypersensitivity to streptokinase, streptodornase, or any component of the formulation.
- Active internal bleeding or conditions with a high risk of hemorrhage.
- Recent surgery, trauma, or invasive procedures.
- Severe uncontrolled hypertension.
Adverse Reactions
- Local irritation, pain, or burning at the application site.
- Allergic or hypersensitivity reactions, including rash, urticaria, and rarely anaphylaxis.
- Increased risk of bleeding or hemorrhage if absorbed systemically.
Drug Interactions
- Concomitant use of anticoagulants (e.g., heparin, oral anticoagulants) increases the risk of hemorrhage.
- Antiplatelet agents (e.g., NSAIDs, aspirin) may potentiate bleeding risks.
- Other local enzymatic agents or irritating topical treatments may increase skin or wound irritation.
Curated Content: Needs Vetting Before Put to Clinical Use