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BLOOD AND BLOOD FORMING ORGANS › OTHER HEMATOLOGICAL AGENTS › OTHER HEMATOLOGICAL AGENTS › Drugs used in hereditary angioedema
conestat alfa
B06AC04
Forms & Strengths
- Powder for injection 50 mg
- Lyophilized powder for injection 50 mg
Adult Dosing
- Initial dose 50-100 mg IV, followed by 50 mg IV every 6 hours
- Titrate dose based on clinical response and serum alpha-1 antitrypsin levels
Pediatric Dosing
- Not established for patients under 18 years old
- Use with caution in pediatric patients due to limited clinical data
Indications
- Treatment of alpha-1 antitrypsin deficiency
- Short-term treatment of emphysema due to alpha-1 antitrypsin deficiency
Mechanism of Action
- Replaces endogenous alpha-1 antitrypsin to protect lungs from damage by proteolytic enzymes
- Increases serum alpha-1 antitrypsin levels to normal or above-normal levels
Contraindications
- IgA deficiency with known antibodies against IgA
- History of anaphylaxis or severe systemic reactions to alpha-1 antitrypsin
Adverse Reactions
- Injection site reactions
- Headache
- Fatigue
- Dizziness
- Allergic reactions
- Anaphylaxis
Drug Interactions
- No known interactions with other medications
- Caution with other intravenous products due to potential for incompatibility or interference
Curated Content: Needs Vetting Before Put to Clinical Use