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voxelotor

B06AX03

Forms & Strengths

Tablets: 500 mg
Tablets: 300 mg
Tablets: 1000 mg

Adult Dosing

Adults: 1500 mg orally once daily
Titrate dose based on hemoglobin response

Pediatric Dosing

Pediatrics: Safety and efficacy not established
Use in pediatric patients not recommended

Indications

Sickle cell disease: to increase hemoglobin levels and reduce anemia
Treatment of sickle cell disease in adults and children 12 years and older

Mechanism of Action

Hemoglobin S polymerization inhibitor
Reduces sickling of red blood cells
Increases hemoglobin levels and reduces anemia

Contraindications

None established

Adverse Reactions

Headache
Fatigue
Nausea
Diarrhea
Vomiting
Abdominal pain
Pyrexia

Drug Interactions

Concomitant use with CYP3A4 inhibitors may increase voxelotor levels
Concomitant use with CYP3A4 inducers may decrease voxelotor levels

Curated Content: Needs Vetting Before Put to Clinical Use