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CARDIOVASCULAR SYSTEM › CARDIAC THERAPY › ANTIARRHYTHMICS, CLASS I AND III › Antiarrhythmics, class Ia
quinidine
C01BA01
Forms & Strengths
- Tablets: 200mg, 300mg
- Sulfate injection: 80mg/mL
- Gluconate injection: 50mg/mL
Adult Dosing
- Atrial fibrillation: 200-400mg q6-12h
- Ventricular arrhythmias: 200-400mg q6-12h
- Conversion of atrial fibrillation: 400-600mg q2h
Pediatric Dosing
- Not established for children under 12 years old
- Atrial fibrillation: 2-4mg/kg q6-8h for children >12 years
- Ventricular arrhythmias: 2-4mg/kg q6-8h for children >12 years
Indications
- Atrial fibrillation
- Ventricular arrhythmias
- Paroxysmal supraventricular tachycardia
Mechanism of Action
- Class I antiarrhythmic
- Blocks sodium channels
- Prolongs repolarization
- Decreases automaticity
Contraindications
- Hypersensitivity to quinidine
- Digitalis toxicity
- Heart block or atrioventricular block
- Myasthenia gravis
Adverse Reactions
- Gastrointestinal upset
- Cinchonism
- Hypotension
- Cardiac arrhythmias
- Thrombocytopenia
Drug Interactions
- Digitalis: increased toxicity
- Procainamide: increased risk of toxicity
- Neuromuscular blockers: increased effect
- Phenytoin: decreased quinidine levels
Curated Content: Needs Vetting Before Put to Clinical Use