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CARDIOVASCULAR SYSTEM › CARDIAC THERAPY › ANTIARRHYTHMICS, CLASS I AND III › Antiarrhythmics, class Ic
ethacizine
C01BC09
Forms & Strengths
- Tablets: 25mg, 50mg
- Injectable: 25mg/mL
Adult Dosing
- Angina pectoris: 25-50mg orally 2-3 times a day
- Arrhythmias: 25-100mg orally or IV as a single dose
Pediatric Dosing
- Not established for children under 12 years old
- Children over 12 years: use adult dosing with caution
Indications
- Treatment of angina pectoris
- Treatment of supraventricular and ventricular arrhythmias
- Prophylaxis of atrial fibrillation
Mechanism of Action
- Class I antiarrhythmic agent
- Blocks sodium channels in the heart
- Prolongs effective refractory period
Contraindications
- Hypersensitivity to ethacizine or other Class I antiarrhythmics
- Severe heart failure or cardiogenic shock
- Concomitant use with other antiarrhythmic agents
Adverse Reactions
- Cardiovascular: worsening of arrhythmia, hypotension
- Gastrointestinal: nausea, vomiting
- Neurological: dizziness, headache, fatigue
Drug Interactions
- Other antiarrhythmic agents: increased risk of arrhythmias
- Quinidine: increased risk of QT interval prolongation
- Beta blockers: increased risk of bradycardia and hypotension
Curated Content: Needs Vetting Before Put to Clinical Use