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CARDIOVASCULAR SYSTEM › CARDIAC THERAPY › ANTIARRHYTHMICS, CLASS I AND III › Antiarrhythmics, class III
dofetilide
C01BD04
Forms & Strengths
- Capsules: 125mcg, 250mcg, 500mcg
- Available in generic form
Adult Dosing
- 500mcg BID, initiate in hospital with monitoring
- Adjust dose based on QTc interval
- Maximum dose: 500mcg BID, minimum dose: 125mcg BID
Pediatric Dosing
- Safety and efficacy not established in pediatric patients
- Use in pediatric patients not recommended
Indications
- Atrial fibrillation or atrial flutter
- Maintenance of normal sinus rhythm in patients with symptomatic AF/AFL
- Conversion of AF/AFL to sinus rhythm
Mechanism of Action
- Potassium channel blocker
- Prolongs repolarization, increases effective refractory period
- Class III antiarrhythmic
Contraindications
- Hypokalemia, hypomagnesemia
- Congenital long QT syndrome
- Baseline QTc >440msec (males), >450msec (females)
Adverse Reactions
- Torsades de pointes, ventricular tachycardia
- Headache, dizziness, nausea
- Diarrhea, abdominal pain, fatigue
Drug Interactions
- Ketoconazole, itraconazole, trimethoprim/sulfamethoxazole, cimetidine
- Verapamil, megestrol, prochlorperazine, dolutegravir
- Concomitant use with other QT-prolonging agents not recommended
Curated Content: Needs Vetting Before Put to Clinical Use