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CARDIOVASCULAR SYSTEM › CARDIAC THERAPY › CARDIAC STIMULANTS EXCL. CARDIAC GLYCOSIDES › Adrenergic and dopaminergic agents
oxedrine
C01CA08
Forms & Strengths
- Injectable solution: 10 mg/mL
- Oral solution: 5 mg/mL
- Tablet: 20 mg
Adult Dosing
- Hypotension (Acute): 2-10 mg IV slowly or IM
- Hypotension (Chronic): 10-20 mg orally 2-3 times daily
Pediatric Dosing
- Safety and efficacy in pediatric patients not established
- Use generally avoided unless strictly indicated
Indications
- Acute hypotension
- Orthostatic hypotension
- Support of blood pressure during spinal anesthesia
Mechanism of Action
- Direct and indirect sympathomimetic amine
- Stimulates alpha- and beta-adrenergic receptors
- Increases myocardial contractility and causes peripheral vasoconstriction to raise blood pressure
Contraindications
- Hypersensitivity to oxedrine or sympathomimetics
- Severe hypertension
- Pheochromocytoma
- Tachyarrhythmias or ventricular fibrillation
- Concomitant use with MAO inhibitors
Adverse Reactions
- Hypertension
- Tachycardia or reflex bradycardia
- Palpitations
- Arrhythmias
- Anxiety, headache, or tremor
- Myocardial ischemia in vulnerable patients
Drug Interactions
- MAO inhibitors: May cause severe hypertensive crisis
- Halogenated hydrocarbon anesthetics: Increased risk of ventricular arrhythmias
- Beta-blockers: May antagonize cardiovascular effects and lead to excessive alpha-mediated vasoconstriction
- Tricyclic antidepressants: May potentiate sympathomimetic effects
Curated Content: Needs Vetting Before Put to Clinical Use