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CARDIOVASCULAR SYSTEM › CARDIAC THERAPY › CARDIAC STIMULANTS EXCL. CARDIAC GLYCOSIDES › Adrenergic and dopaminergic agents
metaraminol
C01CA09
Forms & Strengths
- Injection: 10mg/mL
- Injection: 5mg/mL
Adult Dosing
- Initial dose: 0.5-1mg IV, repeat as needed
- Maintenance dose: 2-10mcg/min IV infusion
- Maximum dose: 10mg IV
Pediatric Dosing
- Not established for children under 12 years
- Use with caution and at lower doses in pediatric patients
Indications
- Treatment of hypotension associated with anesthesia
- Treatment of hypotension associated with trauma or shock
- Emergency treatment of hypotension
Mechanism of Action
- Alpha-1 adrenergic receptor agonist
- Increases vascular tone, causing vasoconstriction
- Increases cardiac output, blood pressure, and venous return
Contraindications
- Hypersensitivity to metaraminol
- Pheochromocytoma
- Thyrotoxicosis
- Ventricular tachycardia or fibrillation
Adverse Reactions
- Headache
- Dizziness
- Nausea and vomiting
- Palpitations and tachycardia
- Increased peripheral resistance and blood pressure
Drug Interactions
- Tricyclic antidepressants: increased risk of hypertension
- Halogenated anesthetics: increased risk of arrhythmias
- Monoamine oxidase inhibitors: increased risk of hypertension
- Other sympathomimetic agents: additive effects and increased risk of adverse reactions
Curated Content: Needs Vetting Before Put to Clinical Use