← Search & browse all drugs
CARDIOVASCULAR SYSTEM › CARDIAC THERAPY › CARDIAC STIMULANTS EXCL. CARDIAC GLYCOSIDES › Adrenergic and dopaminergic agents
dopexamine
C01CA14
Forms & Strengths
- Intravenous infusion: 1 mg/mL in 5 mL ampoules
Adult Dosing
- Continuous IV infusion: 0.5 to 6 mcg/kg/min
- Titrate carefully based on heart rate, blood pressure, and clinical response
- Initial starting dose typically 0.5 to 1 mcg/kg/min
Pediatric Dosing
- Safety and efficacy in pediatric patients have not been established
Indications
- Short-term treatment of severe heart failure
- Support of circulation in low cardiac output states
- Perioperative hemodynamic optimization
Mechanism of Action
- Synthetic analog of dopamine
- Acts primarily as a potent agonist at dopamine DA1 and DA2 receptors
- Exerts modest agonist activity at beta-2 adrenergic receptors
- Produces peripheral vasodilation and positive inotropic effects
- Increases renal blood flow and sodium excretion
Contraindications
- Hypersensitivity to dopexamine or sulfites
- Phaeochromocytoma
- Mechanical obstruction to ventricular filling or ejection (e.g., severe aortic stenosis)
- Uncorrected hypovolemia
Adverse Reactions
- Tachycardia and tachyarrhythmias
- Hypotension
- Nausea and vomiting
- Tremor
- Hypokalemia
- Headache
Drug Interactions
- Beta-blockers may antagonize the cardiovascular and renal effects of dopexamine
- General anesthetics (e.g., halothane) may increase the risk of arrhythmias
- Monoamine oxidase inhibitors (MAOIs) can potentiate vascular effects
Curated Content: Needs Vetting Before Put to Clinical Use