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CARDIOVASCULAR SYSTEM › CARDIAC THERAPY › CARDIAC STIMULANTS EXCL. CARDIAC GLYCOSIDES › Adrenergic and dopaminergic agents
gepefrine
C01CA15
Forms & Strengths
- Oral drops 7.5%
- Injectable solution (historical/regional)
Adult Dosing
- Orthostatic hypotension: 15 to 30 drops (approx. 37.5 to 75 mg) orally 1 to 3 times daily
- Acute hypotensive states: Dosing varies by regional clinical protocol and route
Pediatric Dosing
- Safety and efficacy in pediatric patients not well established
- Use generally avoided unless under specialized pediatric cardiovascular supervision
Indications
- Orthostatic hypotension
- Circulatory regulation disorders
- Functional hypotension
Mechanism of Action
- Direct and indirect sympathomimetic amine
- Stimulates alpha- and beta-adrenergic receptors
- Increases peripheral vascular resistance and venous return to improve blood pressure
Contraindications
- Hypersensitivity to gepefrine or sympathomimetics
- Severe hypertension
- Pheochromocytoma
- Thyrotoxicosis
- Angle-closure glaucoma
Adverse Reactions
- Tachycardia and palpitations
- Elevated blood pressure / hypertensive episodes
- Anxiety, restlessness, or tremor
- Headache
- Insomnia
Drug Interactions
- Monoamine oxidase inhibitors (MAOIs) can precipitate severe hypertensive crises
- Other sympathomimetic agents increase risk of cardiovascular adverse effects
- Beta-blockers may lead to severe peripheral vasoconstriction and paradoxical hypertension
- General anesthetics (e.g., halogenated hydrocarbons) may increase arrhythmogenicity
Curated Content: Needs Vetting Before Put to Clinical Use