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CARDIOVASCULAR SYSTEM › CARDIAC THERAPY › CARDIAC STIMULANTS EXCL. CARDIAC GLYCOSIDES › Adrenergic and dopaminergic agents
midodrine
C01CA17
Forms & Strengths
- Tablet: 2.5mg, 5mg, 10mg
- Oral solution: 5mg/5mL
Adult Dosing
- Initial dose: 2.5mg-5mg three times a day
- Titrate dose: up to 10mg three times a day
- Maximum dose: 30mg/day
- Take during daytime hours
Pediatric Dosing
- Limited data available
- Use with caution, not approved for pediatric use
Indications
- Orthostatic hypotension treatment
- Neurogenic orthostatic hypotension treatment
Mechanism of Action
- Alpha-1 adrenergic receptor agonist
- Increases vascular tone and peripheral resistance
Contraindications
- Hypertension
- Pheochromocytoma
- Thyroid disorders
- Glaucoma
- Urinary retention
Adverse Reactions
- Headache
- Dizziness
- Nausea
- Pruritus
- Piloerection
- Supine hypertension
Drug Interactions
- Antihypertensive agents: may worsen supine hypertension
- Fluoxetine and other SSRIs: may increase blood pressure
- Digoxin: may increase risk of supine hypertension
- MAOIs: use with caution
Curated Content: Needs Vetting Before Put to Clinical Use