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CARDIOVASCULAR SYSTEM › CARDIAC THERAPY › CARDIAC STIMULANTS EXCL. CARDIAC GLYCOSIDES › Adrenergic and dopaminergic agents
arbutamine
C01CA22
Forms & Strengths
- Intravenous injection: 5mg/mL
- Powder for injection: 10mg/vial
- Solution for injection: 10mg/2mL
Adult Dosing
- Initial dose: 10mcg/kg/min, titrate up to 20mcg/kg/min
- Maintenance dose: 10-20mcg/kg/min
- Maximum dose: 40mcg/kg/min
Pediatric Dosing
- Neonates and infants: 5-10mcg/kg/min, titrate to effect
- Children: 5-20mcg/kg/min, titrate to effect
Indications
- Severe heart failure
- Cardiogenic shock
- Low cardiac output syndrome
Mechanism of Action
- Direct-acting adrenergic agonist
- Increases heart rate and contractility
- Dilates peripheral blood vessels
Contraindications
- Hypersensitivity to arbutamine
- Uncontrolled atrial or ventricular tachyarrhythmias
- Severe obstructive cardiomyopathy
Adverse Reactions
- Hypotension
- Hypertension
- Tachycardia
- Ventricular arrhythmias
- Increased lactate levels
Drug Interactions
- Beta blockers: may reduce effects
- Calcium channel blockers: may potentiate hypotension
- Other inotropes: may increase risk of arrhythmias
Curated Content: Needs Vetting Before Put to Clinical Use