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CARDIOVASCULAR SYSTEM › CARDIAC THERAPY › CARDIAC STIMULANTS EXCL. CARDIAC GLYCOSIDES › Adrenergic and dopaminergic agents
combinations
C01CA30
Forms & Strengths
- Tablets: 6.25mg/12.5mg, 6.25mg/25mg
- Injectable solution: 0.2mg/5mg per 2ml
- Fixed-dose combination
Adult Dosing
- Initial dose: 6.25mg/12.5mg daily, titrate to 25mg/50mg as needed
- Maximum dose: 12.5mg/25mg twice daily
- Administer once or twice daily, with no more than 2 doses in 24 hours
Pediatric Dosing
- Not recommended for children under 18 years old
- Use with caution in pediatric patients, adjust dose according to weight
Indications
- Treatment of hypertension
- Heart failure
- Left ventricular dysfunction
Mechanism of Action
- Combination of an ACE inhibitor and a thiazide-like diuretic
- Blocks the conversion of angiotensin I to angiotensin II
- Inhibits the reabsorption of sodium and chloride in the kidneys
Contraindications
- Hypersensitivity to the active substances or excipients
- Anuria, severe renal impairment
- Concomitant use of aliskiren in patients with diabetes
Adverse Reactions
- Hypotension
- Cough
- Dizziness
- Electrolyte disturbances
- Renal dysfunction
Drug Interactions
- Potassium-sparing diuretics: increased risk of hyperkalemia
- Lithium: increased risk of lithium toxicity
- NSAIDs: decreased antihypertensive effect
- Other antihypertensive agents: increased risk of hypotension
Curated Content: Needs Vetting Before Put to Clinical Use