← Search & browse all drugs
CARDIOVASCULAR SYSTEM › CARDIAC THERAPY › VASODILATORS USED IN CARDIAC DISEASES › Other vasodilators used in cardiac diseases
dilazep
C01DX10
Forms & Strengths
- Tablets: 25mg, 50mg, 100mg
- Injectable solution: 5mg/mL, 10mg/mL
- Capsules: 25mg, 50mg
Adult Dosing
- Angina pectoris: 50-100mg orally 3-4 times a day
- Myocardial infarction: 25-50mg orally every 6-8 hours
- Coronary spasms: 50-100mg orally as needed
Pediatric Dosing
- Safety and efficacy in pediatric patients not established
- Dosing for pediatric patients is not recommended
Indications
- Treatment of angina pectoris
- Management of coronary spasms
- Post-myocardial infarction
Mechanism of Action
- Calcium channel blocker
- Inhibits influx of calcium ions into cardiac muscles and vascular smooth muscles
- Dilates coronary arteries and peripheral arteries
Contraindications
- Hypersensitivity to dilazep or other calcium channel blockers
- Severe hypotension
- Cardiogenic shock
- Sick sinus syndrome
Adverse Reactions
- Headache
- Dizziness
- Hypotension
- Bradycardia
- Nausea
- Vomiting
Drug Interactions
- Beta blockers: increased risk of bradycardia and hypotension
- Digoxin: increased risk of digitalis toxicity
- Cimetidine: increased bioavailability of dilazep
- Theophylline: decreased bioavailability of theophylline
Curated Content: Needs Vetting Before Put to Clinical Use