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CARDIOVASCULAR SYSTEM › CARDIAC THERAPY › VASODILATORS USED IN CARDIAC DISEASES › Other vasodilators used in cardiac diseases
cloridarol
C01DX15
Forms & Strengths
- Oral tablets 50 mg
- Intravenous solution 20 mg/mL
Adult Dosing
- Oral: 50 mg to 100 mg three times daily
- Intravenous: 20 mg to 40 mg slowly infused over 5 to 10 minutes for acute coronary insufficiency
Pediatric Dosing
- Safety and efficacy in pediatric patients not established
Indications
- Management of coronary insufficiency
- Prophylaxis and treatment of angina pectoris
Mechanism of Action
- Coronary vasodilator acting directly on vascular smooth muscle
- Increases coronary blood flow and myocardial oxygen supply
Contraindications
- Hypersensitivity to cloridarol
- Recent myocardial infarction with severe hypotension
- Severe shock or cardiogenic collapse
Adverse Reactions
- Transient headache
- Dizziness and flushing
- Hypotension and tachycardia
- Gastrointestinal upset
Drug Interactions
- Potentiation of hypotensive effects with antihypertensive agents and vasodilators
- Additive cardiovascular depression with beta-blockers or calcium channel blockers
Curated Content: Needs Vetting Before Put to Clinical Use